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. 2019 Jan 10;8:426. doi: 10.3389/fcimb.2018.00426

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Copyright © 2019 Jannuzzi, de Almeida, Amarante-Mendes, Romera, Kaihami, Vasconcelos, Ferreira, de Almeida and Ferreira.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TLR3-3 induce a decreased of fungal burden. WT and TLR3^−/− mice (7 animals/group) were infected with 1 × 10⁶ yeast cells of Pb18 strain. After 30 days, the lung were obtained and we evaluated: (A) CFU and (B) histopathology (Grocott stain) from WT and TLR3^−/− mice, (C) granulomatous process in WT and TLR3^−/− mice. In B, red arrow indicates the fungus and in C, indicate the inflammatory cells. (D) Total areas of lesions in the lung of mice (n = 10). Dates are means of five independents experiments (**P < 0,001 and *P < 0.05).