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. 2019 Jan 10;9:1545. doi: 10.3389/fphar.2018.01545

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Copyright © 2019 Zhao, Wen, Gupta, Lei, Cai, Liang, Yang, Chen and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The cytotoxicity of Y₆ in parental and ABCG2-overexpressing cells. (A) Cytotoxicity of Y₆ was evaluated in parental NCI-H460 and ABCG2-overexpressing NCI-H460/MX20 cells. (B) Cytotoxicity of Y₆ was evaluated in transfected HEK293/pcDNA3.1 and ABCG2-overexpressing HEK293/ABCG2-482-R2 cells. Cells were incubated with different concentration of Y₆ for 72 h. Survival rate was determined by MTT assay. Representative curves were shown as cell survival rate verses concentration of compounds. Points and error bars display the mean and SD.