FIG 2.

TNF-α and LPS primary screens. (A) In the TNF-α primary screen, most genes have a Z-score of between −2 and +2, as evident from the smooth line in that interval. Only 232 genes have a Z-score lower than the cutoff of −2 (marked by the dashed line). They include known genes for NF-κB regulators, such as NEMO and p65, and the TNF-α-specific regulator TNF receptor 1 (TNFR1). (B) Correspondingly, in the LPS primary screen, most genes also have a Z-score of between −2 and +2, as evident from the smooth line in that interval. Only 104 genes have a Z-score lower than the cutoff of −2 (marked by the dashed line). They include genes for known NF-κB regulators, such as NEMO and p65, and the LPS-specific regulator Toll-like receptor 4 (TLR4).