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SNW1 binds to splicing factors in the basal (but not TNF-α-treated) state. THP-1 cells were treated with TNF-α for 30 or 60 min, immunoprecipitated for SNW1, and probed for its binding partners. The splicing factors PRPF8 (SNRNP220) and SNRNP200 appear to bind to SNW1 under basal conditions (absence of TNF-α) but lose that binding 30 min after TNF-α treatment, only to partially regain it 60 min after TNF-α treatment.
