(A) ROC curve when staining intensity in tumor tissue was applied to predict tumor grade (OR = 0.96, AUC = 0.55); (B) ROC curve when proportion of positive GRP78 staining in tumor tissue was applied to predict tumor grade (OR = 0.95, AUC = 0.50); (C) ROC curve when staining intensity in tumor tissue was applied to predict tumor size (OR = 0.99, AUC = 0.52); (D) ROC curve when proportion of positive GRP78 staining in tumor tissue was applied to predict tumor size (OR = 4.26, AUC = 0.53); (E) ROC curve when staining intensity in tumor tissue was applied to predict whether there is a presence of distant metastasis (OR = 1.08, AUC = 0.50); (F) ROC curve when proportion of positive GRP78 staining in tumor tissue was applied to predict whether there is a presence of distant metastasis (OR = 1.93, AUC = 0.54). Abbreviations: AUC, area under the curve; ccRCC, clear cell renal cell carcinoma; OR, odds ratio; ROC, receiver operating characteristics.