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. 2019 Jan 17;14(1):e0210607. doi: 10.1371/journal.pone.0210607

Fig 3. Polyphenolic regulation of endothelial cell proliferation.

Fig 3

Proliferation of HMEC-1 cells measured by WST-1 proliferation assays. HMEC-1 cells which had been transduced with lentiviral particles encoding N1ICD under the control of a doxycycline inducible promoter were used. One-way ANOVA followed by Bonferroni’s post-hoc tests was performed to determine statistical significance. Differing letters represent statistical significant differences. Data represents n = 6. Polyphenols which inhibit HMEC-1 proliferation in a Notch dependent manner include RSVT, APIG, CHRY, MYRI and GENI. LUTE and PICE inhibit HMEC-1 proliferation during both basal and high Notch activity. PTER and QUER do not alter HMEC-1 proliferation.