Table 2. Correlation between gene expression levels as determined in the uveal melanoma samples from the TGCA cohort of patients.
HLAA | HLAB | HLAC | HLAF | HLAG | HLAH | HLADMA | HLADMB | HLADOA | HLADOB | HLADPA | HLADQA1 | HLADQB1 | HLADRA | PDL1 | PDL2 | B7H3 | TNFRSF6B | GAL9 | CD47 | CD200 | HVEM | CD155 | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HLAA | 1 | 0.81 | 0.807 | 0.685 | 0.286 | 0.962 | 0.717 | 0.651 | 0.717 | 0.468 | 0.755 | 0.67 | 0.603 | 0.687 | 0.572 | 0.51 | 0.284 | 0.1 | 0.317 | -0.041 | -0.156 | 0.368 | -0.099 |
HLAB | 0.81 | 1 | 0.899 | 0.919 | 0.252 | 0.824 | 0.816 | 0.848 | 0.892 | 0.735 | 0.862 | 0.814 | 0.793 | 0.882 | 0.748 | 0.752 | 0.015 | 0.262 | 0.411 | 0.246 | -0.119 | 0.133 | -0.058 |
HLAC | 0.807 | 0.899 | 1 | 0.793 | 0.272 | 0.837 | 0.713 | 0.724 | 0.841 | 0.523 | 0.783 | 0.625 | 0.616 | 0.762 | 0.673 | 0.593 | 0.032 | 0.232 | 0.396 | 0.208 | 0.001 | 0.233 | -0.099 |
HLAF | 0.685 | 0.919 | 0.793 | 1 | 0.195 | 0.665 | 0.84 | 0.936 | 0.933 | 0.909 | 0.891 | 0.845 | 0.892 | 0.962 | 0.701 | 0.887 | -0.026 | 0.211 | 0.24 | 0.302 | -0.051 | 0.044 | -0.005 |
HLAG | 0.286 | 0.252 | 0.272 | 0.195 | 1 | 0.336 | 0.089 | 0.107 | 0.116 | 0.07 | 0.132 | 0.176 | 0.079 | 0.12 | 0.349 | 0.119 | 0.024 | 0.114 | 0.452 | -0.06 | 0.065 | 0.019 | 0.3 |
HLAH | 0.962 | 0.824 | 0.837 | 0.665 | 0.336 | 1 | 0.723 | 0.621 | 0.704 | 0.418 | 0.745 | 0.655 | 0.573 | 0.665 | 0.562 | 0.447 | 0.283 | 0.124 | 0.424 | -0.041 | -0.157 | 0.375 | -0.068 |
HLADMA | 0.717 | 0.816 | 0.713 | 0.84 | 0.089 | 0.723 | 1 | 0.916 | 0.907 | 0.77 | 0.936 | 0.908 | 0.902 | 0.921 | 0.561 | 0.759 | 0.289 | -0.068 | 0.19 | 0.004 | -0.267 | 0.262 | 0.006 |
HLADMB | 0.651 | 0.848 | 0.724 | 0.936 | 0.107 | 0.621 | 0.916 | 1 | 0.96 | 0.893 | 0.952 | 0.925 | 0.954 | 0.988 | 0.659 | 0.875 | 0.018 | 0.045 | 0.123 | 0.227 | -0.13 | 0.084 | -0.028 |
HLADOA | 0.717 | 0.892 | 0.841 | 0.933 | 0.116 | 0.704 | 0.907 | 0.96 | 1 | 0.803 | 0.957 | 0.859 | 0.884 | 0.973 | 0.697 | 0.814 | 0.053 | 0.027 | 0.142 | 0.234 | -0.112 | 0.168 | -0.074 |
HLADOB | 0.468 | 0.735 | 0.523 | 0.909 | 0.07 | 0.418 | 0.77 | 0.893 | 0.803 | 1 | 0.781 | 0.828 | 0.915 | 0.896 | 0.567 | 0.918 | -0.035 | 0.121 | 0.083 | 0.29 | -0.129 | -0.099 | 0.022 |
HLADPA | 0.755 | 0.862 | 0.783 | 0.891 | 0.132 | 0.745 | 0.936 | 0.952 | 0.957 | 0.781 | 1 | 0.926 | 0.926 | 0.966 | 0.627 | 0.787 | 0.123 | -0.003 | 0.175 | 0.112 | -0.174 | 0.218 | -0.066 |
HLADQA1 | 0.67 | 0.814 | 0.625 | 0.845 | 0.176 | 0.655 | 0.908 | 0.925 | 0.859 | 0.828 | 0.926 | 1 | 0.963 | 0.92 | 0.625 | 0.812 | 0.101 | -0.03 | 0.174 | 0.102 | -0.218 | 0.085 | 0.025 |
HLADQB1 | 0.603 | 0.793 | 0.616 | 0.892 | 0.079 | 0.573 | 0.902 | 0.954 | 0.884 | 0.915 | 0.926 | 0.963 | 1 | 0.954 | 0.57 | 0.86 | 0.054 | 0.027 | 0.115 | 0.165 | -0.198 | 0.051 | 0.01 |
HLADRA | 0.687 | 0.882 | 0.762 | 0.962 | 0.12 | 0.665 | 0.921 | 0.988 | 0.973 | 0.896 | 0.966 | 0.92 | 0.954 | 1 | 0.667 | 0.878 | 0.033 | 0.051 | 0.145 | 0.224 | -0.138 | 0.116 | -0.025 |
PDL1 | 0.572 | 0.748 | 0.673 | 0.701 | 0.349 | 0.562 | 0.561 | 0.659 | 0.697 | 0.567 | 0.627 | 0.625 | 0.57 | 0.667 | 1 | 0.732 | -0.092 | 0.144 | 0.403 | 0.489 | -0.084 | -0.127 | -0.099 |
PDL2 | 0.51 | 0.752 | 0.593 | 0.887 | 0.119 | 0.447 | 0.759 | 0.875 | 0.814 | 0.918 | 0.787 | 0.812 | 0.86 | 0.878 | 0.732 | 1 | -0.015 | 0.139 | 0.2 | 0.308 | -0.146 | -0.125 | -0.067 |
B7H3 | 0.284 | 0.015 | 0.032 | -0.026 | 0.024 | 0.283 | 0.289 | 0.018 | 0.053 | -0.035 | 0.123 | 0.101 | 0.054 | 0.033 | -0.092 | -0.015 | 1 | -0.334 | 0.073 | -0.563 | -0.354 | 0.42 | 0.167 |
TNFRSF6B | 0.1 | 0.262 | 0.232 | 0.211 | 0.114 | 0.124 | -0.068 | 0.045 | 0.027 | 0.121 | -0.003 | -0.03 | 0.027 | 0.051 | 0.144 | 0.139 | -0.334 | 1 | 0.569 | 0.25 | 0.028 | -0.184 | -0.185 |
GAL9 | 0.317 | 0.411 | 0.396 | 0.24 | 0.452 | 0.424 | 0.19 | 0.123 | 0.142 | 0.083 | 0.175 | 0.174 | 0.115 | 0.145 | 0.403 | 0.2 | 0.073 | 0.569 | 1 | 0.021 | -0.107 | -0.02 | -0.046 |
CD47 | -0.041 | 0.246 | 0.208 | 0.302 | -0.06 | -0.041 | 0.004 | 0.227 | 0.234 | 0.29 | 0.112 | 0.102 | 0.165 | 0.224 | 0.489 | 0.308 | -0.563 | 0.25 | 0.021 | 1 | 0.144 | -0.353 | -0.184 |
CD200 | -0.156 | -0.119 | 0.001 | -0.051 | 0.065 | -0.157 | -0.267 | -0.13 | -0.112 | -0.129 | -0.174 | -0.218 | -0.198 | -0.138 | -0.084 | -0.146 | -0.354 | 0.028 | -0.107 | 0.144 | 1 | -0.116 | 0.266 |
HVEM | 0.368 | 0.133 | 0.233 | 0.044 | 0.019 | 0.375 | 0.262 | 0.084 | 0.168 | -0.099 | 0.218 | 0.085 | 0.051 | 0.116 | -0.127 | -0.125 | 0.42 | -0.184 | -0.02 | -0.353 | -0.116 | 1 | -0.063 |
CD155 | -0.099 | -0.058 | -0.099 | -0.005 | 0.3 | -0.068 | 0.006 | -0.028 | -0.074 | 0.022 | -0.066 | 0.025 | 0.01 | -0.025 | -0.099 | -0.067 | 0.167 | -0.185 | -0.046 | -0.184 | 0.266 | -0.063 | 1 |