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(A) Gene mutation frequencies in PRECAMA samples are compared with those observed in a dataset of premenopausal women selected from the TCGA and METABRIC BC series [19, 20]. (B) IHC subtype distributions of samples according to their mutation status. Luminal A: ER+/HER2-; luminal B: ER+/HER2+; HER2-enriched: ER-/HER2+; triple-negative: ER-/PR-/HER2-.
