Table 2.

Four patients with structural disease with details

Patient ID	ATA risk at diagnosis	Tg (ng/mL)a	Neck US	Location of metastases	Treatments since initial therapy	Final clinical outcome
14	High	0.7	(−)	L	Surveillance	Structural incomplete
22	High	617.7	(+)	N, M, L	Neck debulking surgery, I-131, systemic therapy	Structural incomplete
30	High	21.6	(+)	N, L, Bo	I-131, neck dissection, EBRT, systemic therapy	Deceased
31	High	47	(−)	L, Bo	EBRT	Structural incomplete

^aAll patients had negative anti-thyroglobulin antibodies at the time of disease detection. The Tg level in table reflects either the level at the time of finding structural disease if that occurred during follow-up or 6 months after initial therapy if structural disease was found at time of diagnosis (n = 1: patient 31)

Tg unstimulated thyroglobulin, US ultrasound, (+) = positive, (−) = negative, N neck, M mediastinum, L lung, Bo bone