Table 4:
Effect of albuterol on exercise hemodynamics
| Placebo (n=15) | Albuterol (n=15) | p value | |
|---|---|---|---|
| Heart Rate, bpm | −2 ± 4 | +3 ± 9 | 0.07 |
| Mean Arterial BP, mmHg | +3 ± 12 | −7 ± 9 | 0.01 |
| Systolic Arterial BP, mmHg | +3 ± 11 | −6 ± 13 | 0.03 |
| Diastolic Arterial BP, mmHg | −1 ± 7 | −5 ± 6 | 0.07 |
| SVR, WU | +0.5 ± 1.9 | −1.7 ± 2.0 | 0.005 |
| Ventricular Filling pressures | |||
| RA pressure, mmHg | −1 ± 2 | −5 ± 3 | 0.0007 |
| PCWP, mmHg | −3 ± 3 | −2 ± 6 | 0.7 |
| LV Transmural pressure, mmHg | −1 ± 2 | +3 ± 5 | 0.006 |
| Pulmonary Vascular Function | |||
| PA systolic pressure, mmHg | −3 ± 6 | −10 ± 5 | 0.002 |
| PA mean pressure, mmHg | −2 ± 4 | −8 ± 4 | 0.0002 |
| PVR, Wood units | +0.1 ± 0.7 | −0.6 ± 0.5 | 0.003 |
| PA compliance, ml/mmHg | +0.0 ± 0.7 | +1.6 ± 1.6 | 0.001 |
| PA Ea, mmHg/ml | −0.05 ± 0.11 | −0.17 ± 0.11 | 0.004 |
| Right Ventricular Function | |||
| RV s’, cm/s | +0.4 ± 1.1 | +1.1 ± 1.6 | 0.2 |
| TAPSE, mm | +0.5 ± 1.3 | +0.6 ± 0.8 | 0.8 |
| RV FAC, % | −1 ± 3 | +1 ± 3 | 0.3 |
| RV-PA Coupling | |||
| RV s’/PA mean, cm.s−1/mmHg | +0.02 ± 0.05 | +0.13 ± 0.12 | 0.003 |
| TAPSE/PA mean, mm/mmHg | +0.04 ± 0.07 | +0.17 ± 0.12 | 0.002 |
| FAC/PA mean, %/mmHg | +0.09 ± 0.17 | +0.44 ± 0.31 | 0.006 |
| Integrated Indices | |||
| Stroke volume, ml | −0.3 ± 2.1 | +1.6 ± 2.8 | 0.04 |
| Cardiac output, L/min | +0.1 ± 1.0 | +2.0 ± 2.1 | 0.004 |
Values are mean ± SD. Table shows baseline corrected values (exercise values after receiving study drug minus exercise values prior to study drug) Abbreviations as in Table 2.