Table 4.
Detailed analysis of characteristics of sepsis episodes identified in the VPS explicit codes cohort, the reference standard cohort, or both.
| Patient characteristicsaracteristic | Both Cohorts Sepsis Registry (+) VPS Search (+) (n=292) | Reference Cohort Only Sepsis Registry (+) VPS Search (–) (n=109) | VPS Cohort Only Sepsis Registry (–) VPS Search (+) (n=223) | pa |
|---|---|---|---|---|
| Age in years, median (IQR) | 8 (2–14) | 4 (1–13) | 7 (2–14) | 0.073 |
| Admitted from inpatient unit, n (%) | 72 (25) | 27 (25) | 68 (30) | 0.292 |
| PIM-2 risk of mortality, median (IQR) | 3.1 (1.1–5.0) | 2.0 (0.9–4.2) | 1.4 (1.0–4.5) | 0.034* |
| PRISM-III score, median (IQR) | 9 (5–15) | 7 (3–13) | 7 (3–12) | 0.013* |
| Oncologic diagnosis, n (%) | 59 (20) | 14 (13) | 40 (18) | 0.247 |
| Conventional mechanical ventilation, n (%) | 187 (64) | 71 (65) | 114 (51) | 0.005* |
| Advanced modes of ventilationb, n (%) | 55 (19) | 17 (16) | 28 (13) | 0.155 |
| Extracorporeal support, n (%) | 10 (3) | 2 (2) | 4 (2) | 0.443 |
| PICU LOS in days among survivors, median (IQR) | 9 (4–19) | 7 (3–19) | 4 (2–11) | <0.001* |
| PICU mortality, n (%) | 28 (10) | 6 (6) | 18 (8) | 0.414 |
a
Comparisons across all three groups assessed by Kruskal-Wallis test for continuous variables and Chi-squared test for categorical variables.
b
Advanced modes of ventilation include high frequency oscillatory ventilation, volume diffusive respirator, and airway pressure release ventilation.
*
Significance at the α = 0.05 level
Abbreviations:
PIM = pediatric index of mortality; PRISM = pediatric risk of mortality; PICU = pediatric intensive care unit; LOS = length of stay