Table 2.

Frontal Cortex cytokine profile

	Vapor (35 days)				Withdrawal (1day)				Recovery (28 days)
	% Ctrl	MWU	Z	P	% Ctrl	MWU	Z	P	% Ctrl	MWU	Z	P
IL-1α	148.9	11	−0.3	0.74	84.7	6.5	−1.2	0.23	87.4	7.5	−0.6	0.52
IL-1β	94.8	20	−0.6	0.57	95	17.5	−0.5	0.62	84	5	−1.8	0.07
IL-12p70	112.3	23.5	−0.1	0.9	82	8.5	−1.9	0.06	90.5	9	−1.1	0.26
IL-17A	99.1	24	−0.1	0.95	87.5	12	−1.3	0.2	87.3	9.5	−1	0.31
IL-18	92.1	19	−0.7	0.48	107.9	18	−0.4	0.67	93.2	12	−0.5	0.58
TNF α	118.7	17	−1	0.32	92.4	10	−1.7	0.09	91.6	8.5	−1.2	0.22
	% Ctrl	MWU	Z	P	% Ctrl	MWU	Z	P	% Ctrl	MWU	Z	P
IL-4	101.7	22.5	−0.3	0.8	92.3	16	−0.7	0.47	88.1	6.5	−1.6	0.12
IL-5	127.8	12	−0.9	0.36	72.5	8.5	−1.6	0.1	90.7	7	−0.5	0.59
IL-10	103.4	22	−0.3	0.75	87	12	−1.3	0.2	77.4	8	−1.3	0.2
IL-13	141.5	17.5	−0.1	0.94	69.5	6	−1.7	0.09	101	14	−0.2	0.85
	% Ctrl	MWU	Z	P	% Ctrl	MWU	Z	P	% Ctrl	MWU	Z	P
Eotaxin	104.2	23.5	−0.1	0.9	95.1	9.5	−1.7	0.09	96.9	7.5	−1.5	0.13
Fractalkine	92.5	14	−1.3	0.18	98.7	18	−0.4	0.67	114.3	3	−2.2	0.03
IP-10	70.8	11	−1.7	0.09	120.7	8	−1.9	0.06	96.9	13	−0.4	0.72
LIX	102.8	21.5	−0.4	0.7	97.2	6.5	−2.1	0.04	99.3	8.5	−1.2	0.23
RANTES	101.6	19	−0.7	0.48	105	13	−1.1	0.25	92.6	8	−1.3	0.2
	% Ctrl	MWU	Z	P	% Ctrl	MWU	Z	P	% Ctrl	MWU	Z	P
HMGB1	103.2	24	−0.1	0.95	74.1	10	−1.5	0.14	75.6	5	−2.2	0.03
NF-κB	112.1	16	−1.1	0.28	88.6	16	−0.6	0.56	91.1	18	−0.3	0.77
TLR4	121.7	17	−1	0.34	87.1	14	−0.9	0.38	98.4	20	0	1

Percent control (% ctrl) equivalent of the means presented in vapor exposed animals for each cytokine at three time points. Non-parametric statistical results from Mann Whitney U (MWU), Zscore (Z) and P value (p) shown. P values less than 0.05 are shown in bold.