Table 3.

Serum cytokine profile

	Vapor (35 days)				Withdrawal (1day)				Recovery (28 days)
	% Ctrl	MWU	Z	P	% Ctrl	MWU	Z	P	% Ctrl	MWU	Z	P
IL-1α	52.2	0	−3.1	<0.01	73	7	−2	0.05	93.5	11	−0.7	0.47
IL-1β	77	9	−2	0.05	55.6	3	−2.6	0.01	80.7	7	−1.5	0.14
IL-12p70	66.2	1	−3	<0.01	81.2	3.5	−2.5	0.01	94.5	11	−0.7	0.46
IL-17A	52.1	0	−3.1	<0.01	74.1	9	−1.7	0.09	86.9	10	−0.9	0.36
IL-18	58.5	5.5	−2.4	0.02	53.6	14	−1	0.32	141.1	10	−0.9	0.36
TNF α	69.1	0	−3.1	<0.01	86.5	7.5	−1.9	0.05	85.6	9.5	−1	0.31
	% Ctrl	MWU	Z	P	% Ctrl	MWU	Z	P	% Ctrl	MWU	Z	P
IL-4	61.9	0	−3.2	<0.01	78.7	6	−2.2	0.03	85.1	10.5	−0.8	0.41
IL-5	78.3	0	−3.1	<0.01	92	12	−1.3	0.2	95.4	11.5	−0.6	0.52
IL-10	52.7	1	−3	<0.01	63	9	−1.7	0.09	90.9	9	0	1
IL-13	51.7	0	−3.1	<0.01	75.9	6.5	−2.1	0.04	88.5	12	−0.6	0.57
	% Ctrl	MWU	Z	P	% Ctrl	MWU	Z	P	% Ctrl	MWU	Z	P
Eotaxin	79	0	−3.1	<0.01	82.5	6	−2.2	0.03	96	12	−0.5	0.58
Fractalkine	87	10	−1.9	0.06	108.2	15	−0.9	0.39	93.9	15	0	1
IP-10	57.7	2	−2.9	<0.01	141.2	14	−1	0.32	116.8	8	−1.3	0.2
LIX	67.8	5	−2.5	0.01	91.1	15	−0.9	0.39	127	11	−0.7	0.47
RANTES	100.9	22	−0.3	0.75	119.7	16	−0.7	0.48	139.9	9	−1.1	0.27
	% Ctrl	MWU	Z	P	% Ctrl	MWU	Z	P	% Ctrl	MWU	Z	P
HMGB1	89.4	24	−0.1	0.95	124.1	13	−1	0.31	100.3	19	−0.1	0.88
NF-κB	113.2	19	−0.7	0.48	174.5	1	−2.8	0.01	101.7	17	−0.4	0.66
TLR4	102.9	20	−0.6	0.57	146.3	5	−2.2	0.03	128	7	−1.9	0.06

Percent control (% ctrl) equivalent of the means presented in vapor exposed animals for each cytokine at three time points. Non-parametric statistical results from Mann Whitney U (MWU), Zscore (Z) and P value (p) shown. P values less than 0.05 are shown in bold.