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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Pharmacol Res. 2018 Jul 17;140:75–84. doi: 10.1016/j.phrs.2018.07.018

Figure 3.

Figure 3.

Inhibition of the 5-HT1B receptor has a protective effect on trabecular bone of DSS-inflamed mice. A. Measurement of trabecular number and trabecular spacing in DSS-inflamed mice receiving the 5-HT1B receptor antagonist GR55562 (1 mg/Kg/day SC, daily) were significantly improved compared to DSS-inflamed mice. They did not, however, reached control levels. B. Representative images from μCT scans of the femoral trabecular bone from two mice per group. Vehicle/Vehicle, n=5; Vehicle/DSS, n=5; GR55562/DSS, n=5. ** P < 0.01, *** P < 0.001, **** P < 0.0001; 1-way ANOVA with Bonferroni’s correction.