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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Pharmacol Res. 2018 Jul 17;140:75–84. doi: 10.1016/j.phrs.2018.07.018

Figure 4.

Figure 4.

Changes in cortical thickness and bone growth in DSS-inflamed mice were partially protected by inhibition of the 5-HT1B receptor. Cortical thickness was protected by inhibition of the 5HT1B receptor with GR55562 (1 mg/Kg/day SC, daily). A. Parameters of cortical bone growth/homeostasis that were decreased in femurs from DSS-inflamed mice included cortical thickness, bone porosity, bone density and bone volume fraction. B. Dual injection of fluorescent calcein was used to measure dynamic bone growth. Decreased spacing of the bands growth in DSS mice correlates with decrease level of bone growth activity. Bone formation in inflamed animals was protected by daily treatment with the 5-HT1B antagonist. Vehicle/Vehicle, n=5; Vehicle/DSS, n=5; GR55562/DSS, n=5. ** P < 0.01, *** P < 0.001; 1-way ANOVA with Bonferroni’s correction.