Fig. 1.

(A) Structure-based sequence alignment of the amino acid residues making up the S1′ and S1—S4 pockets of Plm IV, Plm IX, Plm X and Cat D. (B) Surface representation of the S3 and S4 pockets in Plm IV and Cat D docking models with the hydroxyethylamine based inhibitor (S,R)-1b. The figure was prepared in PyMol [37]. Surface oxygen atoms are colored in red, nitrogens in blue, sulfurs in yellow and hydrogens and carbons in grey. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)