Table 5.
Combining selectivity inducing structural motives in analogues (S,R)-5a,b
| Comp. | R | IC50 Plm IV, μΜ |
IC50 Cat D, μΜ |
Sa |
|---|---|---|---|---|
| (S,R)-5a | t-BuCH2 | 0.076 | 3.8 | 50.0 |
| (S,R)-5b | CF3CH2CH2 | 0.15 | 4.9 | 32.6 |
a
Selectivity factor of Plm IV/Cat D inhibition.
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