Table 7.
Substitution pattern of compounds in Scheme 2.
| R1 | R2 | No. | No. | No. | Comments |
|---|---|---|---|---|---|
| Et | Et | 14a | 15a | (S,R)-2a | from rac–11 (step f) |
| Me | Me | 14b | 15b | (S,R)-2b | |
| HOCH2CH2 | HOCH2CH2 | 14c | 15c | (S,R)-2c | |
| MeOCH2CH2 | MeOCH2CH2 | 14d | 15d | (S,R)-2d | |
| CF3CH2CH2 | CF3CH2CH2 | 14e | 15e | (S,R)-2e | |
| (CH3)2CHCH2 | (CH3)2CHCH2 | 14f | 15f | (S,R)-2f | from rac–11 (step f) |
| H | MeOC(CH3)2CH2 | 14g | 15g | (S,R)-3a | |
| H | c-PrCH2 | 14h | 15h | (S,R)-3b | from rac–11 (step f) |
| H | HOCH2CH2CH2 | 14i | 15i | (S,R)-3c | |
| H | CF3CH2CH2 | 14j | 15j | (S,R)-3d | from rac–11 (step f) |
| H | HOC(CH3)2CH2 | 14k | 15k | (S,R)-3e | |
| H | MeOCH2CH2 | 14l | 15l | (S,R)-3f | |
| H | Me2NCH2CH2 | 14m | 15m | (S,R)-3g | |
| H | t-BuCH2 | 14n | 15n | (S,R)-3h | from rac–11 (step f) |
| H | HOCH2C(CH3)2 | 14o | 15o | (S,R)-3i | |
| H | HOCH2CH2 | 14p | 15p | (S,R)-3j | |
| H | PhCH2 | 14q | 15q | (S,R)-3k | from rac–11 (step f) |
| H | t-BuOCH2CH2 | 14r | 15r | (S,R)-3l | |
| H | c-HexCH2 | 14s | 15s | (S,R)-3m |