Table A1.
Characterization of prototype devices
| Attribute | Target | Prototypes | |
|---|---|---|---|
| Design parameters | Device size | 1–1.5 mm D x 10 mm L | Measured surface area 79 mm2 (±12 mm2); Estimated cylindrical geometry 1.3 mm D x 10 mm L* |
| Protein load | >3 mg | 3.2 mg (±0.4 mg) | |
| PEG load | 0.9 mg | 0.88 mg (±0.08 mg) | |
| Total solid load (protein, excipients, PEG) |
5 mg | 5.45 mg (±0.65 mg) | |
| Porous area | ½ of device surface area (31–47 mm2) |
39 mm2 (±6 mm2) | |
| System parameters | Release rate | 30 μg/day | 25 μg/day |
| Area‐normalized Release rate |
0.76 μg/(mm2·day) | 0.64 μg/(mm2·day) | |
| PEG3350 reservoir Concentration |
70 mg/ml | 66 mg/ml (± 3 mg/ml)1 | |
| Protein reservoir Solubility |
7 mg/ml | 8 mg/ml (± 1 mg/ml) |