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. 2019 Jan 11;9:3234. doi: 10.3389/fmicb.2018.03234

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Copyright © 2019 Peng, Wang, Gide, Zhu, Lamabadu Warnakulasuriya Patabendige, Li, Cai and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Design of LHD fusion protein. (A) Diagram of LHD containing catalytic domain of the lysin from phage phiC2 (LCD), a linker (GGGGS)₃, and human alpha-defensin protein HD₅. LHD has 226 amino acids with a PI of 9.10 and MW of 24.4 kDa. (B) Amino acid sequence of LHD; sequence of LCD is marked in gold; sequence of the linker is marked in green; and sequence of the HD₅ protein is marked in red.