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. 2019 Jan 11;9:3234. doi: 10.3389/fmicb.2018.03234

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Copyright © 2019 Peng, Wang, Gide, Zhu, Lamabadu Warnakulasuriya Patabendige, Li, Cai and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LHD is effective in the treatment of CDI in mice. Twenty BL6/C57 mice were divided into two groups (n = 10). One group of mice was infected with C. difficile R20291 spores and treated with LHD, and the other group was infected with R20291 spores and treated with PBS as control. The experimental scheme and treatment plan is illustrated in Figure 2, and described in Methods and Materials. Weight changes (A), percentage of diarrhea (B,C), survivals of two group mice (D) were plotted. Mice in group “R20291+LHD” lost significantly less weight in postinfection days 1 and 2 (p < 0.05, marked in dash box region) (A).