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. 2019 Jan 11;9:3007. doi: 10.3389/fimmu.2018.03007

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Copyright © 2019 Opasawatchai, Amornsupawat, Jiravejchakul, Chan-in, Spoerk, Manopwisedjaroen, Singhasivanon, Yingtaweesak, Suraamornkul, Mongkolsapaya, Sakuntabhai, Matangkasombut and Loison.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NETs are associated with severe DENV infection. Serum samples from healthy donors as well as mild (DF) and severe (DHF) DENV infected patients during febrile illness (Feb DENV) and convalescent phase (Con DENV) were used for the MPO-DNA ELISA. (A,B) O.D. ratios from the same DF and DHF patients are connected with lines. Analysis was performed with the Wilcoxon-signed rank test, *p < 0.05. (C) Each symbol represents O.D. at 450 nm normalized to inter-experimental control. Mann–Whitney U-test, *p < 0.05.