Figure 1.
Eosinophil-deficient mice decreased inflammatory cells into airways after A. fumigatus infection. WT and ΔdblGATA-1 mice were infected via intranasal with 40 μL of suspension containing 1 × 108 conidia of A. fumigatus. BALFs were harvested at 1 and 3 days after infection for inflammatory cell infiltrates determination. Lungs were harvested at 1 and 3 days after infection for NAG, MPO and EPO determination. (A) Total cells, (B) neutrophils, (C) macrophages, (D) lymphocytes and (E) eosinophils count in BALF. (F) MPO (G) NAG and (H) EPO assays. Data are presented as Mean ± SD (n = 5 to 7 mice per group). *Significantly different (P < 0.05) compared WT to knockout mice. #Significantly different (P < 0.05) between mice with varied times of infection.