Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 11;9:1888. doi: 10.3389/fphys.2018.01888

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Whittaker, Hancox and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Effects of the N588K-hERG mutation at the single cell and whole human atria level. (Ai) Single cell action potential profiles under WT (blue), WT-N588K (green), and N588K (red) conditions at a pacing frequency of 1 Hz, with corresponding current traces for (Aii) I_Kr, (Aiii) I_K1, (Aiv) I_Ks, and (Av) I_CaL, and (Avi) a summary of the measured APD₉₀. (B) Activation-recovery interval (ARI) maps under (i) WT, (ii) WT-N588K, and (iii) N588K conditions. (Ci) View looking into the cavities of the 3D anatomical human atria model, with the following regions highlighted: crista terminalis (CT), left atrium (LA), pectinate muscles (PM), pulmonary veins (PV), and right atrium (RA). (Cii) Measured dispersion of activation-recovery interval, ΔARI, between different atrial regions under WT and SQT1 mutation conditions.