Figure 7.

Arrhythmia termination in 3D anatomical human atria by representative concentrations of disopyramide, propafenone, and quinidine under SQT1 mutation conditions. (A) Snapshots of re-entrant scroll waves in a clockwise configuration (viewed from RA posterior wall) at various time points after initiation of a scroll wave in the 3D anatomical human atrial model under (i) drug-free WT-N588K conditions, and upon application of (ii) 5 μM disopyramide (DISO), (iii) 0.5 μM propafenone (PROPAF), and (iv) 2 μM quinidine (QUIN) conditions, with (B) corresponding pseudo ECG recorded during the final 5.0 s. In pharmacological simulation drugs were applied at t = 2,500 ms. (C) Barcharts summarizing DF upon application of various concentrations of (i) DISO, (ii) PROPAF, and (iii) QUIN for clockwise and anti-clockwise initial conditions (ICs 1 and ICs 2, respectively). ^* denotes simulations in which DF was not calculated due to occurrence of re-entry termination.