Figure 4.

Treatment of diabetic mouse wounds with siRNA‐loaded lipid nanoparticles enabled complete wound healing within 13 days. Mice were wounded on Day 1 and dosed with either PBS (black circles, control) or LNPs containing siRNA specific against TNFα (red squares) on Days 2 and 3. LNP treatment accelerated wound healing over a period of 2 weeks and closed wounds by Day 13 in three of the five mice. The remaining two mice required sacrifice prior to complete treated wound closure. Error bars represent s.d. significance is compared to PBS treated wounds on each day (n = 5, *p < .05, **p < .01, ***p < .001)