Figure 2.

Illustration of breast cancer brain metastasis models. (a) IC injection of tumor cells allows for direct establishment of brain metastases. (b) Following ICD injection into the left ventricle, tumor cells can head to brain vasculature, as well as to other organs. Some cells will successfully extravasate and form macroscopic brain tumors. (c) After IV injection, most tumor cells will arrest in the lung capillary bed, as well as other sites, followed by subsequent metastasis to the brain