Figure 4.

Brain uptake of therapeutics is model‐dependent in tumor, but not healthy tissue. (a) Brain uptake in BT474‐Gluc tumor tissue as calculated by percent injected dose per g of tissue for different treatments. (b) Percent injected dose in healthy brain tissue. Brain uptake was determined 24 hr after a 4 mg/kg dose (CPT basis). Data shown are the average of four mice per treatment group. Error bars indicate SE. ND, not detectable. p values for pairwise comparisons are provided in Supporting Information Tables S8 and S9