Table 5.
Multivariable analyses of binary outcomes in the CholeS dataset
| Surgery > 90 min | Converted to open | 30-day complications | 30-day reintervention | |||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | p value | |
| Nassar grade | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||||
| 1 | 1 | – | 1 | – | 1 | – | 1 | – |
| 2 | 1.81 (1.52–2.15) | < 0.001 | 2.07 (0.81–5.26) | 0.129 | 1.27 (1.05–1.55) | 0.014 | 1.10 (0.89–1.36) | 0.370 |
| 3 | 4.47 (3.76–5.31) | < 0.001 | 12.26 (5.51–27.29) | < 0.001 | 1.41 (1.13–1.75) | 0.002 | 1.22 (0.97–1.55) | 0.094 |
| 4–5 | 14.24 (11.44–17.74) | < 0.001 | 115.6 (52.9–252.9) | < 0.001 | 3.18 (2.48–4.08) | < 0.001 | 2.91 (2.23–3.80) | < 0.001 |
| Age (years) | 0.035 | 0.119 | 0.002 | 0.001 | ||||
| < 40 | 1 | – | 1 | – | 1 | – | 1 | – |
| 40–49 | 1.26 (1.04–1.53) | 0.020 | 1.67 (0.91–3.06) | 0.096 | 0.81 (0.64–1.02) | 0.070 | 0.77 (0.60–0.99) | 0.039 |
| 50–64 | 1.27 (1.06–1.51) | 0.008 | 1.94 (1.13–3.32) | 0.016 | 0.69 (0.55–0.86) | < 0.001 | 0.62 (0.49–0.79) | < 0.001 |
| 65+ | 1.23 (1.02–1.47) | 0.028 | 1.68 (0.97–2.92) | 0.067 | 0.94 (0.75–1.17) | 0.576 | 0.79 (0.62–1.01) | 0.064 |
| BMI | < 0.001 | NS | NS | NS | ||||
| ≤ 30 | 1 | – | – | – | – | – | – | – |
| 31–35 | 1.11 (0.95–1.28) | 0.182 | – | – | – | – | – | – |
| > 35 | 1.42 (1.21–1.66) | < 0.001 | – | – | – | – | – | – |
| Diagnosis | < 0.001 | < 0.001 | NS | NS | ||||
| CBD stone | 1 | – | 1 | – | – | – | – | – |
| Cholecystitis | 0.69 (0.52–0.91) | 0.009 | 0.45 (0.30–0.68) | < 0.001 | – | – | – | – |
| Colic | 0.55 (0.41–0.74) | < 0.001 | 0.37 (0.23–0.59) | < 0.001 | – | – | – | – |
| Pancreatitis | 0.74 (0.55–1.00) | 0.047 | 0.28 (0.14–0.55) | < 0.001 | – | – | – | – |
| Admission type | < 0.001 | NS | < 0.001 | < 0.001 | ||||
| Elective | 1 | – | – | – | 1 | – | 1 | – |
| Delay | 1.18 (1.00–1.40) | 0.048 | – | – | 1.47 (1.22–1.75) | < 0.001 | 1.48 (1.21–1.81) | < 0.001 |
| Emergency | 1.88 (1.55–2.29) | < 0.001 | – | – | 1.68 (1.35–2.09) | < 0.001 | 2.02 (1.60–2.56) | < 0.001 |
| ASA | NS | 0.004 | < 0.001 | 0.023 | ||||
| 1 | – | – | 1 | – | 1 | – | 1 | – |
| 2 | – | – | 1.68 (1.12–2.50) | 0.011 | 1.19 (0.99–1.42) | 0.061 | 1.16 (0.95–1.41) | 0.139 |
| 3 | – | – | 2.38 (1.48–3.82) | < 0.001 | 1.66 (1.28–2.15) | < 0.001 | 1.54 (1.16–2.05) | 0.003 |
| 4–5 | – | – | 0.67 (0.08–5.60) | 0.711 | 3.37 (1.28–8.85) | 0.014 | 1.83 (0.58–5.79) | 0.304 |
| CBD dilation | 1.55 (1.30–1.84) | < 0.001 | – | NS | 1.29 (1.07–1.55) | 0.008 | 1.46 (1.20–1.78) | < 0.001 |
| CT | – | NS | – | NS | 1.28 (1.05–1.56) | 0.014 | 1.21 (0.97–1.50) | 0.084 |
| ERCP | 0.82 (0.65–1.04) | 0.098 | – | NS | – | NS | – | NS |
| Thick-walled gallbladder | – | NS | – | NS | 0.69 (0.58–0.82) | < 0.001 | 0.72 (0.60–0.87) | < 0.001 |
Results are from multivariable binary logistic regression models, using a backwards stepwise variable selection approach, and with all factors in Supplementary Table 3 considered for inclusion
NS not selected for inclusion in the final model by the stepwise procedure
Bold p values are significant at p < 0.05