Table 3.

Univariate and multivariate analysis (DFS) for all locally HR + tumours with available RS

Variable	Coding	Univariate HR (95% CI)	p value	Multivariate HR (95% CI)	p value
RS	Fractionally ranked	2.33 (1.73–3.14)*	<0.001	1.73 (1.21–2.47)*	0.001
Nodal status
	pN1-3 vs pN0	1.55 (1.11–2.15)	0.009	NS
	pN2-3 vs pN0-1	3.23 (2.11–4.94)	<0.001	2.24 (1.27-3.96)	0.005
	pN3 vs pN0-2	6.35 (3.34–12.07)	<0.001	2.88 (1.27–6.52)	0.011
Tumour stage	pT2-4 vs pT1	1.77 (1.27–2.47)	0.001	1.49 (1.04–2.15)	0.04
Grade
Local assessment	Grade 3 vs grade 1/2	2.36 (1.69–3.29)	<0.001	1.68 (1.13–2.51)	0.02
Central assessment	Grade 3 vs grade 1/2	2.47 (1.77–3.43)	<0.001	1.77 (1.18–2.67)	0.01
Ki-67 (%), semi- quantitative	Fractionally ranked	2.66 (1.88–3.75)*	<0.001	NS
ER (%)	Fractionally ranked	0.75 (0.53–1.05)*	0.10	NS
PR (%)	Fractionally ranked	0.53 (0.39–0.72)*	<0.001	NS
IHC4	Fractionally ranked	2.04 (1.47–2.83)*	<0.001	NS

* 75th to 25th percentile

CI confidence interval, ER oestrogen receptor, HR hazard ratio, NS nonsignificant, PR progesterone receptor, RS recurrence score

Significant p values are specified in bold