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. 2019 Jan 17;9:164. doi: 10.1038/s41598-018-36631-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representative histological pictures and schematic illustration of the colonic lesion induced after irradiation (4 weeks). In control (non-irradiated) animal, crypts are organized and aligned on the muscularis mucosa. The irradiated area was separated into three zones: (1) The regenerative zone with elongated and organized crypts. (2) The dystrophic zone, characterized by the presence of disorganized crypts with a small edema. Colitis cystica profunda(*) could appear in the most inflamed area. (3) The ulcerated zone where crypts were totally absent and replaced by a dense inflammatory infiltrate with an important edema (<-> arrows) and extracellular matrix remodeling.