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. 2019 Jan 17;9:177. doi: 10.1038/s41598-018-36025-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibitory effects of bile acids on the DNA affinity of RamR. (a) Inhibitory effects of cholic or chenodeoxycholic acid on the DNA-binding affinity of RamR analyzed by SPR. DNA was immobilized onto a sensor chip and purified RamR protein was passed over the sensor surface in the presence or absence of bile acids at the various concentrations indicated. (b) Inhibitory effects were calculated from the results of SPR analysis. Percentage binding was calculated relative to the amount of RamR-binding to DNA in the absence of bile acids, which was assigned as 100%. The result of one of three experiments that produced similar data is shown. SPR, surface plasmon resonance.