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. 2019 Jan 17;9:192. doi: 10.1038/s41598-018-36718-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TcHMGB overexpression affects nuclear structure and the protein localization. Confocal Immunofluorescence microscopy of non-induced (Tet−) and induced (Tet+) (0.5 μg/ml tetracycline, 12 h) T. cruzi Dm28c/pTcINDEX-GW-TcHMGB(HA)₂ epimastigotes, trypomastigotes and amastigotes. The nucleus and kinetoplast were labeled with DAPI (blue); rabbit anti-TcHMGB (a-TcHMGB) was revealed with Cy3-conjugated anti-rabbit IgG antibodies (red). Arrows indicate the nucleolar region and open arrows the kinetoplast. Scale bar: 1 μm.