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. 2019 Jan 17;9:193. doi: 10.1038/s41598-018-36969-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic illustration of the human TNF locus and generation of the hTNF.LucBAC construct. Transcription factor binding sites within the human TNF promoter region (a). A BAC construct containing all the regulatory elements within the human TNF locus was used as a template for genetic recombination of the TNF gene. The firefly luciferase-polyA coding sequence replaced exon 1 downstream of the human TNF promoter (b).