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. 2019 Jan 17;9:166. doi: 10.1038/s41598-018-36622-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Typical vibrational Raman spectra in normal breast tissue from the tumor margin (for the same patient P157 as in Fig. 3), lipid-rich region (blue cross) and glycan-rich regions (red and green cross) in the white light microscopy image (A)) in the high frequency (B,D,F) and in the fingerprint (C,E,G) spectral regions of human breast normal tissue, integration time for a single spectrum 2 s, 10 accumulations, laser power 10 mW, patient P157.