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. 2018 Sep 26;27(2):244–253. doi: 10.1038/s41431-018-0273-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Change in variant effect-size using extreme cases and centenarian controls relative to published effect-sizes, for 29 AD associated genetic variants. Dashed red line at E^k_EA−EC = 1 indicates same effect-size as reported in literature. Orange bars indicate nominal statistical significance for the association with AD (p < 0.05). Stars indicate significant changes of effect-size relative to previously reported effect-sizes (p < 0.05, two-sample z-test)