Table 1.

Population characteristics

	Extreme AD Cases (EA)	Centenarian controls (EC)	Normal controls (NC)
Number of individuals	1,073	255	1,664
Females (%)	564 (52.6)	191 (74.9)	893 (53.7)
Age (SD)a	66.4 (7.8)	101.4 (1.3)	66.0 (6.5)
ApoE ε4 (%)	981 (42.7)	44 (8.6)	533 (16.0)
ApoE ε2 (%)	76 (3.5)	78 (15.3)	304 (9.1)

^aAge at onset for extreme Alzheimer’s disease cases, age at study inclusion for extreme controls and normal controls; SD, standard deviation; ApoE, Apolipoprotein E allele count for ε4 and ε2, respectively. Reference to the cohorts reported in this table are: [26, 27, 31, 32]