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. 2019 Jan 17;9:154. doi: 10.1038/s41598-018-36427-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Orphan cdi segments. To the left, the terminal COOH regions of different type-II cdiA genes and the cognate coexpressed cdiI genes are shown. N, C and SWR domains of CT regions are denoted as in Figs 3 and 4. Vestiges of cdiA and cdiI genes, numbered and coloured as the genes from which they were derived, are shown in the orphan region to the right. Pre-toxin and toxin modules are as shown in Fig. 4.