Fig. 5. Anatomical differences in brain region volume in Setd5^+/− adults.

a No genotype-dependent difference in brain volume (409.7 ± 5.29 vs. 417.5 ± 4.16 mm³, t_1,21 = 1.156, P = 0.2606). b No genotype-dependent difference in relative cortex volume (29.81 ± 0.16 vs. 30.09 ± 0.13 mm³, t_1,21 = 1.35, P = 0.1910). c Genotype-dependent difference in relative amygdala volume does not exceed FDR (8.331 ± 0.145 vs. 8.693 ± 0.082 percent, t_1,21 = 2.109, FDR P = 0.21). d No genotype-dependent difference in relative total hippocampus volume (4.842 ± 0.042 vs. 4.885 ± 0.0288 percent, t_1,21 = 0.8351, P = 0.4131). e Coronal series highlighting regional relative size differences with significance exceeding FDR threshold = 0.05 (blue = smaller, red = larger). Statistics: n = 12 (wt) or n = 11 (het) adult brains as independent replicates, with bars representing mean ± SEM. Brain region size normalized to total brain volume. t-test for comparison of group means of 178 brain regions, with statistical significance assigned at F ≥ 4.0, corresponding to FDR P ≤ 0.05