Table 1.
Autophagy pathway qPCR results of CLN5-deficient patient fibroblasts.
| Gene Symbol | Fold Regulation | p-value |
|---|---|---|
| SNCA | +90.3923 | 0.0003 |
| CTSS | +3.6365 | 0.0014 |
| BCL2 | −2.4529 | 0.0095 |
| HGS | −2.3706 | 0.0065 |
| CASP3 | −2.3312 | 0.0008 |
| CDKN1B | −2.1028 | 0.0002 |
| TGFB1 | −2.0955 | 0.0097 |
| PTEN | −2.0499 | 0.0312 |
The genes with expression change (compared to control fibroblasts) >2-fold with a p-value < 0.05 are shown. Three independent qPCR were performed. +, up-regulated; −, down-regulated. The p values were calculated based on a Student’s t-test of the replicate 2(−ΔCt) values for each gene in the control group and the CLN5 patient group.