Table 3.
Soluble inflammatory biomarkers.
| Marker | Mean ± SD at time point | P-value | |
|---|---|---|---|
| T0 | T3 | ||
| CA125 (kU/L) | 27.29 ± 15.57 | 27.67 ± 17.35 | 0.8862 |
| CRP (mg/L) | 4.86 ± 5.178 | 4.55 ± 4.852 | 0.8548 |
| Neopterin (nmol/L) | 14.55 ± 7.552 | 11.25 ± 5.535 | 0.1563 |
| Lactate (nmol/μl) | 75.81 ± 29.04 | 101.2 ± 24.89 | 0.3125 |
| HMGB1 (ng/ml) | 1.437 ± 0.473 | 1.966 ± 0.7599 | 0.3125 |
| PGE2 (pg/ml) | 9367 ± 5982 | 6534 ± 4137 | 0.3125 |
| CA15-3 (pg/ml) | 29163 ± 12464 | 26622 ± 14116 | 0.5625 |
| MIF (pg/ml) | 233768 ± 569219 | 1495 ± 994.4 | 0.8438 |
| Leptin (pg/ml) | 35740 ± 20517 | 33229 ± 21924 | 0.2188 |
| CEA (pg/ml) | 10767 ± 10642 | 7655 ± 6203 | 0.3125 |
| Prolactin (pg/ml) | 13342 ± 4489 | 51089 ± 90081 | 1.0000 |
| BDNF (pg/ml) | 2611 ± 754.7 | 4506 ± 1914 | 0.0625 |
| EGF (pg/ml) | 57.44 ± 33.38 | 97.34 ± 58.7 | 0.2188 |
| Eotaxin (CCL11) (pg/ml) | 127.9 ± 43.43 | 125.4 ± 45.2 | 0.6875 |
| FGF-2 (FGF basic) (pg/ml) | 225.4 ± 311 | 275.2 ± 271.9 | 0.5625 |
| GM-CSF (pg/ml) | Undetectable | Undetectable | N/A |
| GROα (CXCL1) (pg/ml) | 97.76 ± 121.3 | 96.44 ± 107.5 | 0.5625 |
| HGF (pg/ml) | 790.6 ± 348 | 862.6 ± 374.3 | 1.0000 |
| IFNγ (pg/ml) | 68.72 ± 33.59 | 56.03 ± 29.75 | 0.0625 |
| IFNα (pg/ml) | Undetectable | Undetectable | N/A |
| IL-1RA (pg/ml) | Undetectable | Undetectable | N/A |
| IL-1β (pg/ml) | 1.997 ± 1.534 | 2.244 ± 1.655 | 0.3125 |
| IL-1α (pg/ml) | Undetectable | Undetectable | N/A |
| IL-2 (pg/ml) | Undetectable | Undetectable | N/A |
| IL-4 (pg/ml) | Undetectable | Undetectable | N/A |
| IL-5 (pg/ml) | Undetectable | Undetectable | N/A |
| IL-6 (pg/ml) | 23.7 ± 13.81 | 31.2 ± 18.75 | 0.6466 |
| IL-7 (pg/ml) | Undetectable | Undetectable | N/A |
| IL-8/CXCL8 (pg/ml) | Undetectable | Undetectable | N/A |
| IL-9 (pg/ml) | Undetectable | Undetectable | N/A |
| IL-10 (pg/ml) | Undetectable | Undetectable | N/A |
| IL-12p70 (pg/ml) | 2.389 ± 0.4030 | 2.428 ± 0.4384 | 0.8438 |
| IL-13 (pg/ml) | 3.79 ± 2.26 | 4.375 ± 2.243 | 0.6250 |
| IL-15 (pg/ml) | Undetectable | Undetectable | N/A |
| IL-17A (pg/ml) | Undetectable | Undetectable | N/A |
| IL-18 (pg/ml) | 151.2 ± 123.1 | 134.9 ± 65.02 | 0.6875 |
| IL-21 (pg/ml) | Undetectable | Undetectable | N/A |
| IL-22 (pg/ml) | Undetectable | Undetectable | N/A |
| IL-23 (pg/ml) | Undetectable | Undetectable | N/A |
| IL-27 (pg/ml) | 290.1 ± 474.4 | 206.4 ± 381 | 0.4606 |
| IL-31 (pg/ml) | Undetectable | Undetectable | N/A |
| IP-10 (CXCL10) (pg/ml) | 101.1 ± 24.93 | 94.2 ± 15.44 | 0.2188 |
| LIF (pg/ml) | 28.28 ± 55.95 | 28.16 ± 50.19 | 0.8438 |
| MCP-1/CCL2 (pg/ml) | 58.96 ± 28 | 81.36 ± 22.73 | 0.1563 |
| MIP-1α/CCL3 (pg/ml) | 61.12 ± 78.37 | 58.01 ± 67.72 | 1.0000 |
| MIP-1β/CCL4 (pg/ml) | 282.6 ± 179.7 | 273.4 ± 156.7 | 0.6875 |
| βNGF (pg/ml) | 93.28 ± 120 | 104.5 ± 100 | 0.3125 |
| PDGF-BB (pg/ml) | 192.3 ± 102.9 | 243.9 ± 150.6 | 0.3125 |
| PIGF-1 (pg/ml) | 210.8 ± 195.5 | 272 ± 185.8 | 0.4375 |
| RANTES/CCL5 (pg/ml) | 240 ± 31.88 | 248.1 ± 72 | 0.8434 |
| SCF (pg/ml) | 19.19 ± 25.56 | 19.7 ± 23.24 | 0.5625 |
| SDF1α/CXCL12 (pg/ml) | 1372 ± 585.3 | 1349 ± 448.3 | 1.0000 |
| TNFα (pg/ml) | Undetectable | Undetectable | N/A |
| TNFβ/LTA (pg/ml) | Undetectable | Undetectable | N/A |
| VEGF-A (pg/ml) | 999.6 ± 1109 | 1129 ± 994.7 | 0.5625 |
| VEGF-D (pg/ml) | Undetectable | Undetectable | N/A |
This table shows the plasma levels of inflammatory biomarkers as measured by ELISA or luminex. Units are mentioned for each marker. Values are presented as mean ± standard deviations. P-values were calculated using the nonparametric Wilcoxon matched-pairs test with Prism software. Analytes were considered undetectable if values were below detection limit in >50% of samples. T0 – baseline, T3 – day 14 of treatment.