Fig. 6.

Immunofluorescence analysis indicated increased interferon (IFN)-γ⁺ cells in an interleukin (IL)-15-treated mouse model of cerulein-induced chronic pancreatitis. Pancreatic tissue sections were immunostained for intracellular IFN-γ using anti-IFN-γ FITC-labeled antibody followed by DAPI mounting on saline (A and B)-, cerulein (C and D)-, and cerulein with IL-15 (E and F)-treated mice. G: IFN-γ positive cells were quantitated in these tissue sections and expressed as IFN-γ-positive cells/mm². H and I: the presence of IL-15 receptor (IL-15R) on primary isolated pancreatic acinar cells (H) and IL-15-mediated activation of signaling molecule signal transducer and activator of transcription (STAT) 5 (I). Data are presented as means ± SD; n = 6–8 mice/group. All photomicrographs are shown with the original magnification ×400. A representative photomicrograph was presented in each group analyzed.