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. 2018 Aug 28;315(6):E1154–E1167. doi: 10.1152/ajpendo.00155.2018

Fig. 5.

Fig. 5.

miR-21 genetic ablation exacerbates ALDO/SALT-mediated LV fibrosis and inflammation markers protein expression. miR21KO or WT mice were treated with ALDO/SALT or vehicle for 8 wk, and LV protein levels of Ctgf (A), PAI-1 (B), and Nppa (C) were quantified by Western blot. Results are means ± SE (n = 4). *P < 0.05. ALDO, aldosterone; AU, arbitrary unit; Ctgf, connective tissue growth factor; LV, left ventricle; miR-21, microRNA-21; miR21KO, miR-21 knockout; PAI-1, plasminogen activator inhibitor type 1; WT, wild type.