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. 2018 Aug 28;315(6):E1154–E1167. doi: 10.1152/ajpendo.00155.2018

Fig. 8.

Fig. 8.

miR-21 genetic ablation exacerbates miR-21 target gene Sprouty 2 (Spry2) protein levels in ALDO/SALT-mediated cardiac injury. miR21KO or WT mice were treated with ALDO/SALT or vehicle for 2 (left) or 8 wk (center), and left ventricle gene expression was quantified by RT-qPCR for Spry1 (A), Spry2 (B), Pten (C), Pdcd4 (D), and Bcl2 (E). Results are means ± SE (n = 6–8). *P < 0.05. miR21KO or WT mice were treated with ALDO/SALT or vehicle for 8 wk, and left ventricle protein levels were quantified by Western blot (right). Results are means ± SE (n = 4). *P < 0.05. ALDO, aldosterone; AU, arbitrary unit; miR-21, microRNA-21; miR21KO, miR-21 knockout; Pdcd4, programmed cell death 4; Pten, phosphatase and tensin homolog; Spry1, Sprouty 1, WT, wild type.