Fig. 4.

Metabolite correlation network reveals 9 clusters that correspond to distinct metabolic pathways. Hexagons in red represent metabolites and lipid classes that are significantly upregulated in near-term fetal cardiac tissue whereas green hexagons represent metabolite and lipids that are upregulated in newborn cardiac tissue immediately following birth. All other correlated metabolites that were not identified or significantly altered are represented by pink hexagons. Pathways related to amino acid metabolism, glycolysis, and purine metabolism appear as clusters on the left, whereas pathways related to phospholipid and metabolism appear on the right.