Table 1.
Significantly altered metabolites in the newborn compared with fetal heart as identified by HR-MAS
| Relative Mean (SE) |
|||||
|---|---|---|---|---|---|
| Metabolite | Fetal | Newborn | P value | FDR-corrected P value | Log2(FC), N/F |
| 1,2-Propanediol | 0.163 (0.007) | 2.334 (0.336) | 1.08E−06 | 3.86E−06 | 3.84 |
| Ethanol | 0.087 (0.007) | 1.018 (0.220) | 5.27E−04 | 1.10E−03 | 3.55 |
| Lipid (β-CH2) | 0.328 (0.034) | 0.824 (0.171) | 0.01 | 0.03 | 1.33 |
| AMP | 0.067 (0.004) | 0.137 (0.005) | 1.09E−12 | 1.36E−11 | 1.02 |
| Lipid (α-CH2) | 0.454 (0.043) | 0.884 (0.146) | 0.02 | 0.03 | 0.96 |
| Lipid (-CH = CH-) | 0.358 (0.035) | 0.660 (0.124) | 0.04 | 0.07 | 0.88 |
| Glutamate | 1.309 (0.055) | 1.951 (0.073) | 1.94E−07 | 8.09E−07 | 0.58 |
| Hypotaurine | 0.143 (0.007) | 0.205 (0.010) | 5.47E−05 | 1.71E−04 | 0.52 |
| Choline | 0.718 (0.034) | 0.989 (0.043) | 6.82E−05 | 1.89E−04 | 0.46 |
| Scyllo-inositol | 0.434 (0.016) | 0.513 (0.024) | 0.02 | 0.03 | 0.24 |
| Lactate | 3.494 (0.131) | 1.692 (0.068) | 1.12E−13 | 2.79E−12 | −1.05 |
| Succinate | 0.558 (0.036) | 0.278 (0.015) | 6.88E−08 | 3.44E−07 | −1.00 |
| Alanine | 1.357 (0.051) | 0.853 (0.026) | 7.47E−10 | 6.22E−09 | −0.67 |
| Myo-inositol | 4.409 (0.166) | 2.971 (0.083) | 1.65E−08 | 1.03E−07 | −0.57 |
| Dimethylamine | 0.117 (0.007) | 0.079 (0.004) | 1.74E−04 | 4.35E−04 | −0.56 |
| Ethanolamine | 0.290 (0.011) | 0.226 (0.009) | 2.27E−04 | 5.16E−04 | −0.35 |
AMP, adenosine 5′-monophosphate; FDR, false discovery rate; HR-MAS, high-resolution magic angle spinning; FC, fold change; N/F, newborn/fetal.