Mitochondrial state 3 and state 4 respiration in skeletal muscle feed arteries from young, middle-aged, and old subjects. CI, complex I; CI+II, complex I + II, CII, complex II. Values are means ± SE; n = 10 young, 10 middle-aged, and 10 old subjects. *Significantly different from middle-aged and old (P < 0.05).