Table 2.
Average changes in function and myocardial absorbance of the perfused rabbit heart due to cromakalim followed by adenosine
| Control | Cromakalim | Adenosine | n | |
|---|---|---|---|---|
| Coronary vascular resistance, mmHg·min·ml−1 | 1.05 ± 0.14 | 0.45 ± 0.01* | 0.45 ± 0.02 | 4 |
| Coronary flow rate, ml/min | 40 ± 4 | 84 ± 1* | 85 ± 3 | 4 |
| Aortic output, ml/min | 122 ± 13 | 104 ± 13 | 108 ± 13 | 4 |
| Oxygen consumption, μmol O2·min−1·g−1 | 6.7 ± 1.8 | 6.7 ± 0.3 | 6.5 ± 0.2 | 3 |
| Venous Po2, mmHg | 40 ± 15 | 423 ± 11* | 435 ± 13 | 3 |
| Myoglobin (∆OD582) | 0.070 ± 0.019* | 0.074 ± 0.020 | 4 | |
| Cytochrome c (∆OD550) | −0.032 ± 0.009* | −0.031 ± 0.008 | 4 | |
| Cytochrome aa3 (∆OD605) | −0.062 ± 0.019* | −0.064 ± 0.020 | 4 |
Data are means ± SE. Adenosine (80 µM) after cromakalim did not alter cardiac function or myocardial absorbance. OD, optical density.
*
Functional or absorbance measure as a result of cromakalim was significantly different from the paced control.