Fig. 3.
K+ channel inhibitors selectively block the vasodilator response of pial arterioles to endothelin-1 (ET-1). Responses of pial arterioles to ET-1 (10−12–10−8 M) were repeatedly tested in the same animals before (control; n = 10 piglets) and after treatment with the following inhibitors: the ATP-sensitive K+ channel inhibitor glibenclamide (10−7 M) and the large-conductance Ca+-activated K+ channel inhibitor paxilline (4 × 10−5 M), applied alone or in combination (n = 5 piglets/treatment). Values are expressed as means ± SE. *P < 0.05 compared with the corresponding baseline diameter.