Fig. 4.

K⁺ channel inhibitors do not alter vasodilator responses of pial arterioles to the smooth muscle-targeting vasodilators sodium nitroprusside (SNP) and isoproterenol (Iso). Responses of pial arterioles to SNP (10⁻⁶ M; top) and Iso (10⁻⁶ M; bottom) were repeatedly tested in the same animals before (control; n = 10 piglets) and after treatment with the following inhibitors: the ATP-sensitive K⁺ channel inhibitor glibenclamide (10⁻⁷ M) and the large-conductance Ca⁺-activated K⁺ channel inhibitor paxilline (4 × 10⁻⁵ M), applied alone or in combination (n = 5 piglets/treatment). Values are expressed as means ± SE. *P < 0.05 compared with the corresponding baseline diameter.